While many will sympathise with Mrs Mensch's decision to put her family before her political career, the voters of Corby may not be overly impressed by the fact that in doing so she also put her children before them.
Turn-out is likely to be low for what is basically an unnecessary mid-term poll, and the Conservative candidate - whoever they may be - may be punished accordingly.
In his letter of response to her resignation, Mr Cameron hinted that he had greater things in mind for Mrs Mensch than the backbench career she had apparently reveled in, saying he had hoped to see her in a more "senior" position.
This appears to be confirmation of reports that the Prime Minister had hoped to promote her to ministerial office in the government reshuffle he is expected to hold next month.
Ever mindful of the need to modernise his party's image, Mr Cameron will feel the loss of one of the brighter, more telegenic members of the party.
Always popular with television producers and a committed user of social media, Mrs Mensch was one of the few MPs of any party who appeared at tune with the times.
Many were as irritated by her outspoken views as they were impressed.
And with critics saying that she had a tendency to pronounce on issues without thinking them through, and more than a hint of self-promotion about her frequent media appearances, there will be some in the party who will not necessarily be sorry to see the back of her.
Although most thought that these aspects of her personality ruled her out of the higher branches of government, still only 40 there was always the potential for Mrs Mensch to mellow into office, and become a high flyer in ministerial terms.